Rejuran Cannula Is a 'Procedure Method,' Not a Product — How Is It Different from a Needle?

Rejuran Cannula refers to the **treatment technique of injecting Rejuran skin booster using a blunt-tipped tubular instrument (cannula)**. Even with the same Rejuran, factors such as bruising, swelling, pain, and recovery time differ depending on whether it is administered with a conventional needle or a cannula, which is why it has recently become a frequently mentioned term in consultations.

To highlight the key points first: The main ingredient of Rejuran is **PN (polynucleotide)**, extracted and purified from the germ cell DNA of fish such as salmon, and its purpose is not to add volume, but rather to improve the skin's regenerative environment. Because the cannula method creates only a few entry points to disperse and inject over a wide area, it is advantageous for reducing bruising, embossing (raised bumps), and downtime. However, this does not mean that 'a cannula is unconditionally better.' Depending on the area and purpose, needles can sometimes be more suitable.

🧬 Rejuran Cannula, what exactly does it mean?

First, regarding the ingredients: Rejuran line products are skin boosters manufactured by PharmaResearch, and the core ingredient is **PN (polynucleotide)**. It is easy to confuse with PDRN (polydeoxyribonucleotide) due to the similar name; both are nucleic acid-based components, but how they are formulated varies across products. What they have in common is that they act to revitalize the regenerative environment within the skin to help stimulate collagen production.

To this, the tool called a 'cannula' is combined. A cannula is a blunt-tipped tube where the product is dispensed through **side holes** rather than the tip. Its structure is fundamentally different from a standard sharp needle.

In summary, **Rejuran Cannula = Rejuran (ingredient) + Cannula (tool)**. When having a consultation, saying "Please administer Rejuran using a cannula" is the accurate way to express it.

📌 Key Summary: Rejuran Cannula is not a product name, but a 'treatment technique' of dispersedly injecting salmon-derived PN components using a blunt tube.

💉 Cannula vs. Needle, how do they differ?

The biggest difference lies in the number of entry points. Covering the entire face closely with a needle requires roughly 70 to 80 injection points. In contrast, a cannula requires only a few entry points, through which the tube is inserted and moved side-to-side underneath to spread the product widely.

Because a cannula has a blunt tip that tends to push blood vessels aside as it passes through, it works to lower the risk of severe complications such as vascular embolism and skin necrosis. However, this does not mean the 'risk disappears completely.' No injection procedure can entirely rule out that possibility.

Conversely, needles can be more advantageous for delivering the product precisely into the dermal layer. This leads to concerns such as "Doesn't a cannula have less efficacy?", which stems from the worry that the substance might not properly reach the dermis. For this reason, combination methods using both cannulas and needles depending on the area are widely used today.

📌 Key Summary: Cannulas reduce downtime by dispersing broadly through fewer entry points, while needles excel at precise injection into the target layer. They are options to choose from, not competitors.

🩹 How much are bruising, embossing, and downtime actually reduced?

Embossing refers to the raised bumps that form when product is injected into the dermal layer with a needle. Interestingly, this isn't necessarily a bad sign. It is often interpreted as an indicator that the product was placed accurately into the dermis, and it usually subsides naturally within 1 to 3 days. Therefore, an absence of embossing does not mean a lack of effectiveness, nor does its presence mean the procedure failed.

Cannulas rarely cause this embossing and also reduce bruising and swelling. This is why it is preferred by those who have important events ahead or want to quickly return to daily life without visible marks on their face. Still, one cannot guarantee that bruising will not occur at all during the entry point creation and maneuvering of the tube.

Here are general guidelines to help gauge recovery:

• Saunas, steam rooms, alcohol, and strenuous exercise: Usually refrain for 24–48 hours, or several days depending on personal constitution

• If you have an important event: Allow at least 3–7 days of recovery buffer

• If prone to bruising: Allow an ample margin of about 1–2 weeks

📌 Key Summary: Embossing is a normal reaction and can be a sign of precise injection, disappearing within 1–3 days. Cannulas reduce marks, but cannot completely eliminate bruising.

🎯 How is it applied differently by area?

For cannulas, the gauge (thickness) and length are chosen according to the area. For gauge, higher numbers like 23G, 25G, and 27G indicate thinner tubes; lengths range from 25mm, 38mm, and 50mm, up to 70mm when covering broad areas at once.

• Under-eye area: A thin and delicate area. Cannulas are frequently used to lower the risk of bruising, and the dosage is adjusted in 1 mL increments.

• Cheeks & Cheekbones: A representative area where dispersed injection is advantageous due to the wide surface area.

• Nasolabial folds (around the mouth): Approached for regeneration and elasticity improvement; if volume is desired, a procedure of a different nature should be considered.

• Forehead: Being flat and broad, it is well-suited for spreading evenly using a long cannula.

The standard dosage for the entire face is usually around 2 mL, but 4 mL or more may be used depending on skin condition. The notion that "cannulas are unconditionally better for thinner skin" is also a common misconception. In thinner areas, depth control is much more delicate, meaning the practitioner's anatomical understanding and skill level greatly influence the results.

📌 Key Summary: Cannula gauge, length, and dosage vary by area, and the simplistic formula that 'thinner skin always calls for a cannula' does not hold true.

🔍 Is Rejuran a filler? How is it different from similar treatments?

Many people confuse Rejuran with hyaluronic acid fillers. To put it simply, Rejuran is not a filler. Fillers are treatments designed to provide immediate volume, whereas Rejuran is a skin booster that improves the skin's regenerative environment to gradually boost texture and elasticity. Its effects are not instantaneous; rather, they appear gradually over several weeks and become more pronounced after repeated sessions.

Onlif Clinic approaches these texture, elasticity, and hydration concerns through non-surgical skin treatments. We strengthen the skin barrier and moisture levels with skin boosters, while addressing sagging and elasticity through modalities like ultrasound HIFU, radiofrequency RF, and thread lifting. Rather than altering facial features, the goal is to clear away skin concerns that obscure your natural beauty. With the belief that one person cannot excel at everything, we structure our practice so that specialists handle the specific procedures they perform best.

📌 Key Summary: Rejuran is a regenerative skin booster, not a volumizing filler, and its effects emerge gradually over several weeks.

⚠️ Essential Things to Check Before Treatment

Rejuran is distributed as a product approved by the Ministry of Food and Drug Safety, making it essential to make a habit of verifying product authenticity. Additionally, please be sure to inform your clinic in advance if any of the following apply to you:

• Fish or seafood allergies — Crucial because the main ingredient is a fish-derived nucleic acid.

• Taking anticoagulants (aspirin, etc.) — Directly linked to the risk of bruising and bleeding.

• Pregnant or breastfeeding — Not recommended due to insufficient safety data.

If you are concerned about pain, certain Rejuran products contain **lidocaine (a local anesthetic)** to help minimize discomfort. The treatment interval is typically 2 to 4 weeks, commonly starting with about 3 initial sessions followed by maintenance treatments.

📌 Key Summary: Always disclose fish allergies, anticoagulant medications, and pregnancy/breastfeeding status in advance, and confirm product authenticity.

❓ Frequently Asked Questions

Is Rejuran Cannula a separate product or a treatment technique?

It is a treatment technique. It refers to the method of injecting the Rejuran ingredient using a blunt-tipped cannula; there is no standalone product named 'Rejuran Cannula.'

Will I have zero bruising if treated with a cannula?

While it is true that the likelihood of bruising and swelling is lower than with needles, it cannot be considered 'completely zero.' Bruising can still occur at the entry points or during cannula manipulation, so allowing a buffer of 3 to 7 days is safer if you have important events.

Does it mean the treatment was ineffective if embossing doesn't occur?

No. Embossing is merely a mark that appears when needles deliver product precisely into the dermal layer, usually resolving within 1 to 3 days. While cannulas rarely leave these marks, it does not mean the efficacy is diminished.

Is Rejuran a filler? Does it build volume?

No. Rejuran is a skin booster that enhances the skin's regenerative environment, not a filler that adds volume. It is not intended to produce immediate volume increase.

When do the results start to appear?

They are not immediate. Results are typically felt gradually over several weeks, often becoming significantly more pronounced after approximately 3 sessions spaced 2 to 4 weeks apart.

Can I receive it if I have a fish allergy?

Since the primary ingredient is nucleic acid derived from fish, you must disclose this in advance. If you have an allergy history, suitability must be carefully evaluated during consultation.

Can I get treated while pregnant or breastfeeding?

It is not recommended. Because safety data during pregnancy and breastfeeding is insufficient, postponing the procedure during this period is standard practice.

Is a cannula always better than a needle?

No. While cannulas are advantageous for reducing downtime, needles can be superior for precise dermal layer delivery. The choice varies depending on the targeted area and goals, and both methods are often used in tandem.

Rejuran Cannula: Helpful Checklist Before Choosing a Clinic

Even for the same procedure, outcomes and recovery processes vary depending on where, by whom, and how it is performed. Asking the following questions directly during your consultation can help you make an informed decision:

• Do they perform this procedure frequently? — Each clinic has core procedures they specialize in. Check whether they perform Rejuran Cannula treatments regularly.

• Can you verify the products and devices used? — Inquire whether you can confirm the product name and authenticity (whether it is an officially approved product and if there is an unboxing verification process) during your consultation.

• Is the cost breakdown clearly explained? — Rather than just hearing a total price, you need an explanation of which product is being used, how much, and across what areas to make an accurate assessment.

• Is the treatment designed with the entire face in mind? — Even for identical treatments, injection sites and dosages vary depending on facial shape, skin condition, and bilateral asymmetry.

• Are adverse reactions and recovery processes explained first? — Clinics that proactively inform you about potential adverse reactions and coping methods are more dependable than consultations focusing solely on expected improvements.

• Is there a clear follow-up protocol after treatment? — Check whether checkpoints for progress evaluation, contact channels in case of issues, and revisit criteria are clearly established.

How Onlif Clinic Performs Rejuran Cannula

• Divided responsibilities — Operating on the principle that a single physician cannot master every single procedure, Onlif assigns dedicated physicians according to their specialized fields.

• Verifying products and equipment together during consultation — We guide you through the products used and our unboxing verification process during your consultation.

• Cost guidance provided along with breakdown after diagnosis — Because areas, dosages, and treatment scopes differ per individual, we explain exactly what is included and how costs are determined.

• Design considering overall facial balance — Viewing the face across the three pillars of texture, balance, and youthfulness, we formulate plans to refine aspects that obscure your natural expression rather than altering your features.

• Proactive explanation of side effects and recovery — We outline expected changes alongside individual variances, potential adverse reactions, and response measures prior to treatment.

• Monitoring post-procedure progress together — We provide guidance on follow-up visits and communication channels should you need check-ups during your recovery period.

If you are considering Rejuran Cannula, it is best to first evaluate what is possible and what is difficult given your current skin condition. Accurate diagnosis and treatment planning can only be determined through an in-person consultation. Find out more through a consultation at Onlif Clinic in Gangnam.